GENOMIC AND METABOLIC INSTABILITY DURING LONG-TERM FERMENTATION OF AN INDUSTRIAL SACCHAROMYCES CEREVISIAE STRAIN ENGINEERED FOR C5 SUGAR UTILIZATION

Genomic and metabolic instability during long-term fermentation of an industrial Saccharomyces cerevisiae strain engineered for C5 sugar utilization

The genetic stability and metabolic robustness of production strains is one of the key criteria for the production of bio-based products by microbial fermentation on an industrial scale.These criteria were here explored in Tools an industrial ethanol-producer strain of Saccharomyces cerevisiae able to co-ferment D-xylose and L-arabinose with glucos

read more


The hypomethylation of imprinted genes in IVF/ICSI placenta samples is associated with concomitant changes in histone modifications

Although more and more children are born by Assisted Reproductive Technologies (ART), ART safety has not fully been demonstrated.Notably, ART could disturb the delicate step of implantation, and trigger placenta-related adverse outcomes with potential long-term effects, through disrupted epigenetic regulation.We have previously demonstrated that pl

read more